Syria's President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after showing minor symptoms, his office said on Monday.
The pair are in good health and would keep working in isolation at home, the statement said.
Syria has seen a sharp rise in infections since mid-February. Health and aid officials say it remains difficult to gauge the full size of the outbreak given the lack of testing facilities in a fragile health system devastated by a decade of war.
Assad joins a growing list of world leaders who have tested positive for COVID-19, alongside Britain's Boris Johnson, France's Emmanuel Macron and former U.S. President Donald Trump.
Health workers said the authorities underplayed the size of the outbreak for most of last year, when official figures remained low as hospitals were overwhelmed and death notices appeared in newspapers.
The government denied undercounting the figures and has acknowledged in the last two months the country could be on the verge of a major spike.
It has urged people to wear face masks, take sanitary measures and avoid crowded areas.
Iran and Israel targeted each other with missiles and airstrikes early on Saturday after Israel launched its biggest-ever air offensive against its longtime foe in a bid to prevent it from developing a nuclear weapon.
Israeli fire and airstrikes killed at least 35 Palestinians across the Gaza Strip, most of them near an aid distribution site operated by the US-backed Gaza Humanitarian Foundation, local health authorities said.
The death toll from the Air India plane crash in Ahmedabad rose to 270 on Saturday, as grieving families expressed frustration over delays in the release of victims' bodies, many of which were badly charred in the tragedy.
US President Donald Trump urged Iran on Friday to make a deal on its nuclear programme before it faced more attacks from Israel that he said would be "even more brutal."
Israel launched widescale strikes against Iran on Friday, saying it targeted nuclear facilities, ballistic missile factories and military commanders and that this was start of a prolonged operation to prevent Tehran from building an atomic weapon.
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