According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Nadal uncertain over Roland Garros appearance
Spain's Rafael Nadal said on Wednesday that he is not sure if he will be able to play at next month's French Open after pushing through the pain barrier in his comeback from injury.
Arsenal hammer Chelsea to move three points clear at top
Ruthless Arsenal threw down the gauntlet in the Premier League title race with a 5-0 thrashing of London rivals Chelsea to roar three points clear at the top of the table on Tuesday.
Al-Ain seal Asian Champions League final berth despite Al-Hilal loss
Al-Ain advanced to the Asian Champions League final despite losing 2-1 to Saudi Arabia's Al-Hilal in Riyadh on Tuesday, with the side from the UAE completing a 5-4 aggregate victory to progress to next month's decider.
Inter secure Serie A title in heated win over Milan
Inter Milan won their 20th Serie A title on Monday after a 2-1 win at AC Milan gave Simone Inzaghi's side an unassailable lead in the standings.
Bellingham's strike hands Real comeback win over Barcelona
LaLiga leaders Real Madrid's pursuit of a record-extending 36th Spanish title gathered momentum after Jude Bellingham scored a goal in added time to secure a 3-2 comeback win over Barcelona on Sunday.
6:00am - 10:00am
The Business Breakfast is the day’s must listen for the UAE’s business leaders, and those who aspire to be.
10:00am - 1:00pm
Broadcasting every weekday, Georgia Tolley goes beyond the headlines to speak to government ministers, decision makers, analysts and local experts to find out how the news will impact those of us living in the UAE.
John Lyons of Espace Real Estate says there is a slight slowdown in the property market during summer. So we asked him, does this mean prices are negotiable during the summer months?
Lawyer Rebecca Kelly of Clyde & Co. explained why UAE judicial authorities are setting up new offices to deal with financial crime, including money laundering.
Airalo - an eSim company disrupting telco's roaming revenues, has raised $60 million in funding including investment from our own e&.
It sounds like an episode of The Jetsons, but the sight of flying taxis whizzing around our cities could be much closer than you think.
The UAE has said that tougher penalties will come into force from 1st August for not keeping proper corporate tax records.
