Liverpool are first with 49 points, but who will be their main contender?
Reigning champions Manchester City have the chance to move within 11 points of Jurgen Klopp's side - who have had their match with West Ham postponed as they compete in the Club World Cup.
But Pep Guardiola's men will have to beat fellow title contenders Leicester at the Etihad tonight, who are currently second in the Premier League.
Meanwhile, Arsenal fans will have to wait to see their new boss Mikel Arteta in action, as he officially begins his role on Sunday. Freddie Ljungberg will be in charge of the North London side as they take on Everton, who are also under interim boss Duncan Ferguson.
In the other fixtures of the day, Southampton travel to Aston Villa, while Wolves can go fifth with a win over struggling Norwich. Brighton welcome Sheffield United and Crystal Palace go to Newcastle.
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