The place of worship in Kandahar was targeted during Friday prayers.
A large explosion tore through a mosque in the southern Afghan city of Kandahar during Friday prayers, causing heavy casualties, a spokesman of the Taliban government's interior ministry said.
A health official said 15 dead and 31 wounded had been brought to the city's Mirwais hospital but the total was expected to rise, with ambulances still bringing victims in.
Taliban special forces arrived to secure the site and an appeal went out to residents to donate blood for the wounded.
Qari Saeed Khosti said authorities were collecting details of the explosion, which took place days after a suicide bomb attack claimed by IS on another mosque in the northern city of Kunduz that killed scores of people.
Photographs posted by journalists on social media showed many immobile and seriously wounded on the floor of the mosque.
Nematullah Wafa, a former member of the provincial council, said the blast occurred at the Imam Bargah mosque and caused heavy casualties but there was no immediate confirmation of the number of dead and wounded.
One of Afghanistan's worst earthquakes killed more than 800 people and injured at least 2,800, authorities said on Monday, as helicopters ferried the wounded to hospital after they were plucked from the rubble of homes being combed for survivors.
Israel pushed tanks deeper into Gaza City and detonated explosives-laden vehicles in one suburb as airstrikes killed at least 19 people on Monday, Palestinian officials and witnesses said.
India's Narendra Modi told Vladimir Putin on Monday that India and Russia stood shoulder to shoulder even in difficult times after the Kremlin chief cast the Indian prime minister as his "dear friend" and gave him a lift in his armoured limousine.
Chinese President Xi Jinping urged leaders to leverage their "mega-scale market", while Russian President Vladimir Putin showed support for Xi's ambition for a new global security and economic order that poses a challenge to the US during a regional summit on Monday.
South Korea has suspended a military radio broadcast that transmits to North Korea as part of measures aimed at easing tensions with Pyongyang, Seoul's defence ministry said on Monday.
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