According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.


New Zealand clinch ODI series against West Indies
Federer to be inducted into International Tennis Hall of Fame
Tommy Fleetwood set for 2026 Hero Dubai Desert Classic
Iraq defeats UAE in World Cup playoff decider
Bergs sends Belgium past France into Davis Cup semi-finals
