An Israeli strike on a school housing displaced people in Gaza killed at least 20 people and injured dozens, according to local authorities.
Israel stepped up its military operations in the enclave in early May, saying it is seeking to eliminate Hamas' military and governing capabilities and bring back the remaining hostages who were seized in October 2023.
Medics said the dozens of casualties in the strike on the school, in the Daraj neighbourhood of Gaza City, included women and children.
Despite mounting international pressure that pushed Israel to lift a blockade on aid supplies in the face of warnings of looming famine, Prime Minister Benjamin Netanyahu said last week that Israel would control the whole of Gaza.
Israel has taken control of around 77 per cent of the enclave either through its ground forces or evacuation orders and bombardments that keep residents away from their homes, Gaza's media office said.
The Israeli campaign has devastated Gaza and pushed nearly all of its two million residents from their homes.
The offensive has killed more than 53,000 people, many of them civilians, according to Gaza health authorities.
Pakistan said on Saturday it would recommend US President Donald Trump for the Nobel Peace Prize, an accolade that he has said he craves, for his work in helping to resolve the recent conflict between India and Pakistan.
Iran and Israel exchanged fresh attacks early on Saturday, a day after Tehran said it would not negotiate over its nuclear programme while under threat and Europe tried to keep peace talks alive.
UN Secretary-General Antonio Guterres warned on Friday that expansion of the Israel-Iran conflict could "ignite a fire no one can control" and called on both sides and potential parties to the conflict to give peace a chance.
As the air war between Israel and Iran enters its second week, the foreign ministers of Britain, France and Germany are making renewed efforts to draw Iran back to negotiations, while US involvement remains undecided.
Dozens of Palestinians have been killed by Israeli fire in the past two days while trying to access food aid in Gaza, amid a worsening hunger crisis, according to local medics.
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