Jannik Sinner crushed Australia's Thanasi Kokkinakis 6-3 6-0 to reach the third round of Indian Wells and extend his winning streak this season to 13 matches.
The Australian Open champion will next face either 25th seed Jan-Lennard Struff or Croatian Borna Coric.
Elsewhere, Andy Murray fell to Andrey Rublev 7-6(3) 6-1. The Russian will meet Czech 32nd seed Jiri Lehecka in the third round.
Second seed Carlos Alcaraz overcame a sluggish start to dispatch Italy's Matteo Arnaldi 6-7(5) 6-0 6-1 to get his hopes of a title defence in the California desert off to a winning start.
Sixth seed Alexander Zverev and 11th seed Stefanos Tsitsipas both advanced in straight sets, while rising American Ben Shelton came from behind to score a 4-6 6-3 6-4 win over Czech Jakub Mensik in other second round action.
In the women's competition, world number one Iga Swiatek blasted past American Danielle Collins 6-3 6-0, Angelique Kerber upset 10th seed Jelena Ostapenko and defending champion Elena Rybakina withdrew with illness in second round action.
Kerber scored her biggest win in three years with an impressive 5-7 6-3 6-3 victory over hard-hitting Latvian Ostapenko.
In another upset, 22-year-old American Katie Volynets stunned sixth seed Ons Jabeur 6-4 6-4 and will face Caroline Wozniacki in the third round after the Dane outlasted Donna Vekic 7-6(5) 6-3.
Nadal knocked out in French Open first round
Tsitsipas, Swiatek move into French Open second round
Jabeur cruises past wildcard Vickery
Sinner eases past Eubanks at French Open
Asensio misses out as Spain name preliminary Euro 2024 squad
