Novak Djokovic begins his Australian Open title defence against Jeremy Chardy after the draw for the year's first Grand Slam was made on Friday.
World number one Djokovic captured a record-extending eighth title at Melbourne Park last year by beating Dominic Thiem, who is seeded third and faces Mikhail Kukushkin.
Rafael Nadal, seeking a first title at the major since 2009, faces Laslo Djere in his opener.
Reigning women's champion Sofia Kenin will meet wildcard Maddison Inglis.
Top-ranked Ash Barty resumes her quest to become the first homegrown singles winner at the Australian Open since 1978 when the 24-year-old takes on Danka Kovinic.
American Serena Williams, looking to win a record-equalling 24th Grand Slam, meets Laura Siegemund in the opening round while 2019 champion Naomi Osaka faces Anastasia Pavlyuchenkova.
Nadal knocked out in French Open first round
Tsitsipas, Swiatek move into French Open second round
Jabeur cruises past wildcard Vickery
Sinner eases past Eubanks at French Open
Asensio misses out as Spain name preliminary Euro 2024 squad
